2020 May;11(5):1061-1075. doi: 10.1007/s13300-020-00796-z. DeVries JH, Desouza C, Bellary S, Unger J, Hansen OKH, Zacho J, Woo V. Achieving glycaemic control without weight gain, hypoglycaemia, or gastrointestinal adverse events in type 2 diabetes in the SUSTAIN clinical trial programme. 2019 Oct;21(10):2315-2326. doi: 10.1111/dom.13816. Inclusion Criteria: - Japan: Age minimum 20 years - Subjects diagnosed with type 2 diabetes and on stable treatment in a period of 90 days prior to screening with either metformin above or equal to 1500 mg (or maximum tolerated dose), pioglitazone above or equal to 30 mg (or maximum tolerated dose), rosiglitazone above or equal to 4 mg (or maximum tolerated dose) or a combination of either metformin/pioglitazone or metformin/rosiglitazone (doses as for individual therapies). Patient perspectives on once-weekly medications for diabetes. GREATER COMBINED REDUCTIONS IN HbA(1C) ≥1.0% AND WEIGHT ≥5.0% WITH SEMAGLUTIDE VERSUS COMPARATORS IN TYPE 2 DIABETES. An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future. A plethora of GLP-1 agonists: decisions about what to use and when. Full analysis set (FAS=1225) included all randomised subjects who had received at least one dose of semaglutide or sitagliptin. 2018 Sep;20(9):2210-2219. doi: 10.1111/dom.13353. Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults. 2020 Dec 1;105(12). Cardiovasc Diabetol. The Lancet Regional Health – Western Pacific, Advancing women in science, medicine and global health, Correction to Lancet Diabetes Endocrinol 2016; published online April 12. http://dx.doi.org/10.1016/S2213-8587(16)00036-X, Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study, Access any 5 articles from the Lancet Family of journals, https://doi.org/10.1016/S2213-8587(17)30013-X, Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial, Semaglutide: a promising new glucagon-like peptide-1 receptor agonist, Semaglutide, lipid-lowering drugs, and NAFLD, Semaglutide, lipid-lowering drugs, and NAFLD – Author's reply, Recommend Lancet journals to your librarian, American Association of Clinical Endocrinologists, National Institute for Clinical Excellence, UK Prospective Diabetes Study (UKPDS) Group. The other trials were: SUSTAIN-1: A 30-week efficacy and safety trial of semaglutide vs placebo in 388 drug-naive people with type 2 diabetes. 49mins Ram Janmabhoomi trust purchases 7,285-sq.ft adjoining land for ₹1 crore 52mins PM Modi to address conference of top military leadership on … Introduction “What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?” was identified as one of the James Lind Alliance Priority Setting Partnership’s top 10 research questions in cystic fibrosis (CF). Full analysis set (FAS=1225) included all randomised subjects who had received at least one dose of semaglutide or sitagliptin. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). part 1 ... MS Word, PDF, Google Doc, or Evernote. Diabetes Obes Metab. Relationship between weight change and glycaemic control in patients with type 2 diabetes receiving once-weekly dulaglutide treatment. Donnanr et al Open 20199e022577 doi101136bmjopen2018022577 1 Open access Comparative safety of the sodium glucose co-transporter 2 (SGLT2) inhibitors: a systematic review and meta-analysis Jennifer R Donnan,1 Catherine A Grandy,1 Eugene Chibrikov,1 Carlo A Marra,1,2 Kris Aubrey-Bassler,3 Karissa Johnston,1 Michelle Swab,3 Jenna Hache,1 Daniel Curnew,1 Hai Nguyen,1 John-Michael … Key Results. The effect of glucagon-like peptide 1 receptor agonists on weight loss in type 2 diabetes: a systematic review and mixed treatment comparison meta-analysis. Sustain, part 1 4m 31s. Now What? doi: 10.1210/clinem/dgaa577. Information provided by (Responsible Party): This trial is conducted in Africa, Asia, Europe and South America. Keyboard Shortcuts ; Preview This Course. For general information, Learn About Clinical Studies.  (Clinical Trial), Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes (SUSTAIN™ 2 - vs. DPP-4 Inhibitor), Experimental: Semaglutide 0.5 mg + sitagliptin placebo, Experimental: Semaglutide 1.0 mg + sitagliptin placebo, Active Comparator: Sitagliptin 100 mg + semaglutide placebo 1.0 mg, Active Comparator: Sitagliptin 100 mg + semaglutide placebo 0.5 mg, 18 Years and older   (Adult, Older Adult), Nizhniy Novgorod, Russian Federation, 603011, Saint-Petersburg, Russian Federation, 197762, East London, Eastern Cape, South Africa, 5201, Bloemfontein, Free State, South Africa, 9301, Johannesburg, Gauteng, South Africa, 2001, Durban, KwaZulu-Natal, South Africa, 4001, Durban, KwaZulu-Natal, South Africa, 4092, Change in HbA1c (Glycosylated Haemoglobin) From Baseline [ Time Frame: Week 0, week 56 ], Change in Body Weight From Baseline [ Time Frame: Week 0, week 56 ], Change in Fasting Plasma Glucose (FPG) From Baseline [ Time Frame: Week 0, week 56 ], Change in Systolic and Diastolic Blood Pressure From Baseline [ Time Frame: Week 0, week 56 ], Change in Patient Reported Outcome (PRO) Questionnaire Diabetes Treatment Satisfaction Questionnaire Status (DTSQs) From Baseline [ Time Frame: Week 0, week 56 ], Subjects Who Achieved HbA1c Below or Equal to 6.5% (48 mmol/Mol) American Association of Clinical Endocrinologists (AACE) Target (Yes/no) [ Time Frame: After 56 weeks treatment ]. Carlsson Petri KC, Ingwersen SH, Flint A, Zacho J, Overgaard RV. Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): Why Should I Register and Submit Results? 2018 Sep;20(9):2238-2245. doi: 10.1111/dom.13358. ePoster #767 presented 12 Sep 2016 at European Association for the Study of Diabetes - 52nd Annual Meeting. treatment; the main reason for discontinuation was gastrointestinal adverse events Epub 2019 Mar 13. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Combating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes. Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials. 2017 May;5(5):341-354. doi: 10.1016/S2213-8587(17)30092-X. Currently, few researchers think about the carbon footprint of their trial. Diabetes Ther. Change in body weight from baseline to week 56. Continue Assessment. The ‘Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes’ (SUSTAIN-6) was the next CVOT published in 2016.19 Participants were those with T2D who were 50 years of age and older with pre-existing cardiovascular disease, chronic heart failure or chronic kidney disease (stage 3 or higher), or 60 years … Epub 2019 Jul 12. Capehorn M, Ghani Y, Hindsberger C, Johansen P, Jódar E. Once-Weekly Semaglutide Reduces HbA(1c) and Body Weight in Patients with Type 2 Diabetes Regardless of Background Common OAD: a Subgroup Analysis from SUSTAIN 2-4 and 10. This trial is conducted in Asia, Europe and North America. DeSouza C, Cariou B, Garg S, Lausvig N, Navarria A, Fonseca V. Efficacy and Safety of Semaglutide for Type 2 Diabetes by Race and Ethnicity: A Post Hoc Analysis of the SUSTAIN Trials. Epub 2017 Apr 3. Using electronic questionnaires, we aimed to gain a deeper understanding of this research priority. 2018 Aug;9(4):1533-1547. doi: 10.1007/s13300-018-0458-5. Diabetes Metab. Similar results were found in SUSTAIN-6 (Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes) with 0.5 and 1.0 mg doses of semaglutide; heart rate increased by 2.0 and 2.5 bpm, respectively, with robust reductions in A1C at study end (0.7 and 1.0%, respectively), systolic blood pressure (1.3 and 2.6 mmHg, respectively), and weight … Epub 2018 May 29. 2020 Feb 1;105(2). Information supplied with products at the point of sale may be a potentially efficient delivery point for such a countermeasure. Full analysis set (FAS=1225) included all randomised subjects who had received at least one dose of semaglutide or sitagliptin. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study. 2019 Oct;45(5):409-418. doi: 10.1016/j.diabet.2018.12.001. Aroda VR, Ahmann A, Cariou B, Chow F, Davies MJ, Jódar E, Mehta R, Woo V, Lingvay I. [Epub ahead of print] Erratum in: J Clin Endocrinol Metab. 2019 Oct;45(5):409-418. doi: 10.1016/j.diabet.2018.12.001. Epub 2018 Jun 15. Measuring beliefs about taking hypoglycaemic medication among people with Type 2 diabetes. GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial. Standards of medical care in diabetes–2014. Combining the distinct modes of action of these two drug classes has beneficial effects on glucose and weight outcomes. Efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide (HARMONY 2): 52 week primary endpoint results from a randomised, placebo-controlled trial in patients with type 2 diabetes mellitus inadequately controlled with diet and exercise. The SUSTAIN 6 trial demonstrated that once-weekly semaglutide (0.5 and 1.0 mg) significantly reduced major adverse cardiovascular (CV) events (MACE) vs placebo in subjects with type 2 diabetes (T2D) and high CV risk. Credit: Mark Fedkin. Epub 2020 Mar 19. Independent glucose and weight-reducing effects of liraglutide in a real-world population of type 2 diabetic outpatients. Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1-7 trials. Talk with your doctor and family members or friends about deciding to join a study. Regulatory guidance specifies the need to establish the cardiovascular safety of new therapies for type 2 diabetes in order to rule out excess cardiovascular risk.5 The preapproval Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diab…
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