Depression in the elderly is very common. It is used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, and social phobia. If experienced, these tend to have a Severe expression 1. However, it is not possible to predict on the basis of premarketing experience the extent to which a CNS active drug will be misused, diverted, and/or abused once marketed. Read the Medication Guide provided by your pharmacist before you start using venlafaxine and each time you get a refill. Effexor is working really well for me. Effexor Side Effects Overview. Effexor works by preventing the reuptake of serotonin and epinephrine by nerves after they have been released. It is taken by mouth. Effexor (venlafaxine) is an antidepressant used for treatment of major depression. Dizzy 5. ©1996-2021 MedicineNet, Inc. All rights reserved. If you have any questions, ask your doctor or pharmacist. For some, these side effects may decrease after 4-6 weeks of therapy and for others, it may take longer, if they go away at all. This happens with most antidepressants and patients are warned to never stop using the medications without a doctor’s direction. Many people do not recognize the symptoms and warning signs of depression and depressive disorders in children and adults. Get emergency medical help if you have signs of an allergic reaction to Effexor: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat. With... Food cannot prevent depression, but a healthy diet may boost your mood. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Therefore, caution is advised with such patients. Learn more: Mayo Clinic facts about coronavirus disease 2019 (COVID-19) Our COVID-19 patient and visitor guidelines, plus trusted health information; Latest on … Additionally, administration of venlafaxine in a stable regimen did not exaggerate the psychomotor and psychometric effects induced by ethanol in these same subjects when they were not receiving venlafaxine. MedicineNet does not provide medical advice, diagnosis or treatment. Disturbance In The Ability Of The Eye To Focus 2. Follow your doctor's instructions c… Head Pain If experienced, these tend to have a Less Severe expression 1. During its premarketing assessment, multiple doses of venlafaxine tablets, USP were administered to 2897 patients in Phase 2 and Phase 3 studies. These include: Increased depression; Suicidal thoughts; Irritability; Abnormal behaviors; Chest pain; Drowsiness; Blurred vision; Fainting spells; Notify your doctor if these side effects do not go away or are severe. How Long Do The Sexual Side Effects Of Effexor Last? Metoprolol did not alter the pharmacokinetic profile of venlafaxine or its active metabolite, Odesmethylvenlafaxine. Loss Of Appetite 13. Symptoms of teen depression include apathy, irresponsible behavior, sadness, sudden drop in grades, withdrawal from friends, and alcohol and drug use. You may have... Depression in teenagers may be caused by many factors. Don't delay your care at Mayo Clinic. It is unknown if Effexor is secreted in breast milk, and therefore, if it may have an effect on nursing infants. Elle s'utilise pour soigner une dépression. What are the important side effects of Effexor (venlafaxine)? Odesmethylvenlafaxine (ODV) also was unaffected. During its premarketing assessment, multiple doses of venlafaxine hydrochloride extended-release capsules were also administered to 1381 patients in Phase 3 GAD studies and 277 patients in Phase 3 Social Anxiety Disorder studies. But not only is insomnia itself a side effect of the medication, some of its other side effects can also interfere with sleep. Consult your doctor before breastfeeding. Okay so I was on Effexor forever ago when I was in the mental hospital, they kept upping my dosage and told me the side effects would go down after my body got more used to it. Different psychiatric drugs work differently for different people. Second Source article from The Cleveland Clinic. Under steady-state conditions for venlafaxine administered at 150 mg/day, a single 10 mg dose of diazepam did not appear to affect the pharmacokinetics of either venlafaxine or ODV in 18 healthy male subjects. Therefore, no dosage adjustment is required when venlafaxine is coadministered with a CYP2D6 inhibitor. Burning or painful sensations in your chest or throat (heartburn) can also occur during Effexor treatment and may be accompanied by abdominal gas or burping. Venlafaxine, like most anti-depressants, can cause: Increased blood pressure can occur, and blood pressure should be monitored. Effexor ® est contre-indiqué chez les personnes hypersensibles à la venlafaxine ou à une autre substance entrant dans sa composition. Serotonin and norepinephrine are two neurotransmitters released by nerves in the brain. In the tabulations that follow, reported adverse events were classified using a standard COSTARTbased Dictionary terminology. A generic version of Effexor is available. Effexor is the only psych med I’ve tried that seems to be working really well with little side effects. I was fortunate to have only taken this medication for a couple months. Concomitant administration of cimetidine and venlafaxine in a steady-state study for both drugs resulted in inhibition of first-pass metabolism of venlafaxine in 18 healthy subjects. TABLE 2: Treatment-Emergent Adverse Experience Incidence in 4 to 8 Week Placebo-Controlled Clinical Trials1. The clinical significance of elevated 2-OH-desipramine levels is unknown. Effexor (venlafaxine) side effects list for healthcare professionals. In some cases this drug can be used to treat hot flashes and other symptoms of menopause or breast cancer. Constipation 4. The steady-state pharmacokinetics of venlafaxine administered at 150 mg/day were not affected when a single 600 mg oral dose of lithium was administered to 12 healthy male subjects. Psychological side effects of Effexor abuse may also include: Memory problems; Panic attacks; Depression; Vivid dreams; Hallucinations; Confusion; Aggressive behavior; Anxiety; Suicidal thoughts or behaviors; What Are Common Signs and Symptoms of Effexor Addiction? As someone who has taken Effexor XR (venlafaxine HCl), I know all too well what the withdrawal symptoms of this medication are like they can be pure hell. Common Effexor Side Effects. Be sure to contact your doctor if they don't go away or become bothersome. Childhood depression can interfere with social activities, interests, schoolwork and family life. If you come off the medication cold turkey, you may send your body and mind into a state of total shock, depression, anxiety, and disarray. There are many causes and triggers of depression. It is important to emphasize that, although the events reported occurred during treatment with venlafaxine, they were not necessarily caused by it. In vitro and in vivo studies indicate that venlafaxine is metabolized to its active metabolite, ODV, by CYP2D6, the isoenzyme that is responsible for the genetic polymorphism seen in the metabolism of many antidepressants. Venlafaxine tablets, USP treatment (averaged over all dose groups) in clinical trials was associated with a mean increase in pulse rate of approximately 3 beats per minute, compared to no change for placebo. Imipramine did not affect the pharmacokinetics of venlafaxine and ODV. Events are further categorized by body system and listed in order of decreasing frequency using the following definitions: frequent adverse events are defined as those occurring on one or more occasions in at least 1/100 patients; infrequent adverse events are those occurring in 1/100 to 1/1000 patients; rare events are those occurring in fewer than 1/1000 patients. The U.S. Food and Drug Administration warns that antidepressants can cause suicidal thinking and behavior in children and young adults. Should I avoid certain foods while taking Effexor XR? The concomitant use of venlafaxine with a drug treatment(s) that potently inhibits both CYP2D6 and CYP3A4, the primary metabolizing enzymes for venlafaxine, has not been studied. Reported adverse events were classified using a standard COSTART-based Dictionary terminology. Take this medication by mouth as directed by your doctor, usually 2 to 3 times daily with food. Effexor can also cause some terrible side effects in people who try to stop using it too suddenly. The clinical significance of this finding is unknown. Get tips on how to avoid depression and stress during the holiday season. Of the serum chemistry and hematology parameters monitored during clinical trials with venlafaxine tablets, USP, a statistically significant difference with placebo was seen only for serum cholesterol. The 2-OHdesipramine AUCs increased by at least 2.5 fold (with venlafaxine 37.5 mg q12h) and by 4.5 fold (with venlafaxine 75 mg q12h). This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Venlafaxine administered under steady-state conditions at 150 mg/day slightly inhibited the CYP2D6- mediated metabolism of risperidone (administered as a single 1 mg oral dose) to its active metabolite, 9- hydroxyrisperidone, resulting in an approximate 32% increase in risperidone AUC. More serious side effects of Effexor include seizures, stiff muscles, fever, headache, severe nausea, and frequent bruising. What drugs interact with Effexor (venlafaxine)? Selected from data included with permission and copyrighted by First Databank, Inc. See additional information. Or when you don't see the sun for a while? In a study of 9 healthy volunteers, venlafaxine administered under steady-state conditions at 150 mg/day resulted in a 28% decrease in the AUC of a single 800 mg oral dose of indinavir and a 36% decrease in indinavir Cmax. Effexor Side Effects Print Save to bookmarks. Clinically relevant increases in serum cholesterol, defined as 1) a final on-therapy increase in serum cholesterol = 50 mg/dL from baseline and to a value = 261 mg/dL or 2) an average on-therapy increase in serum cholesterol = 50 mg/dL from baseline and to a value = 261 mg/dL, were recorded in 5.3% of venlafaxine-treated patients and 0.0% of placebo-treated patients. However, venlafaxine coadministration did not significantly alter the pharmacokinetic profile of the total active moiety (risperidone plus 9-hydroxyrisperidone). Common Effexor side effects include drowsiness, dizziness, strange dreams, blurred vision, weight fluctuation, mild nausea, and decreased libido. The documented risks of these drugs are provided so the public can make informed, educated decisions. The effects of Effexor on the fetus during pregnancy are unknown. Because CYP3A4 is typically a minor pathway relative to CYP2D6 in the metabolism of venlafaxine, the potential for a clinically significant drug interaction between drugs that inhibit CYP3A4-mediated metabolism and venlafaxine is small. Since uptake is an important mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, the reduced uptake caused by Effexor increases the effect of serotonin and norepinephrine in the brain. Elle agit sur le système nerveux central (SNC) pour redresser l'humeur des personnes atteintes de dépression. Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children, adolescents, and young adults with depression and other psychiatric disorders. Additionally, in a clinical study involving CYP2D6-poor and €“extensive metabolizers, the total concentration of active compounds (venlafaxine plus ODV), was similar in the two metabolizer groups. Accutane (isotretinoin) for Acne linked to birth defects, depression and suicide, Diet and Depression: How Food Can Help with Depression Symptoms, venlafaxine sustained-release - oral, Effexor XR, Cymbalta (duloxetine) vs. Effexor (XR, venlafaxine) Differences in Uses, Dose, and Withdrawal, venlafaxine, Effexor XR (Effexor has been discontinued in the US), Sertraline (Zoloft) vs. Venlafaxine (Effexor). However, for patients with preexisting hypertension, and for elderly patients or patients with hepatic dysfunction, the interaction associated with the concomitant use of venlafaxine and cimetidine is not known and potentially could be more pronounced. All rights reserved. Feeling Weak 11. Common side effects of Effexor include nausea, headaches, anxiety, insomnia, drowsiness, loss of appetite, dizziness, ejaculation disorder, sweating, dry mouth, and weight loss. This table shows the percentage of patients in each group who had at least one episode of an event at some time during their treatment. Effexor side effects. The mechanism explaining this finding is unknown. Feeling Anxious 10. Drowsiness 6. Pregnancy Effexor has been linked to increased risks of miscarriage and birth defects. Combined AUCs of venlafaxine and ODV increased on average by approximately 23% in EMs and 53% in PMs, (range in PMs 4% to 134%). Nervous 14. Caution should be exercised with coadministration of venlafaxine and metoprolol. The FDA suggests if anti-depressants are discontinued abruptly, symptoms may occur such as dizziness, headache, nausea, changes in mood, or changes in the sense of smell, taste, etc. Treatment may involve antidepressants, psychotherapy, or electroconvulsive therapy. Anyone considering the use of venlafaxine or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Effexormay cause side effects. Inability To Have An Erection 12. The sensation can be triggered by moving your eyes and is often accompanied by disorientation, tinnitus (ringing in the ears), vertigo, and/or lightheadedness. Pay close attention to how you feel physically and mentally while taking CBD. The insomnia caused by Effexor has not been thoroughly studied 1 2. In vitro studies indicate that venlafaxine is likely metabolized to a minor, less active metabolite, Ndesmethylvenlafaxine, by CYP3A4. In primate drug discrimination studies, venlafaxine showed no significant stimulant or depressant abuse liability. Others report the sensation spreads out to other parts of the body. Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of metoprolol by approximately 30 to 40% without altering the plasma concentrations of its active metabolite, α-hydroxymetoprolol. © 2005 - 2021 WebMD LLC. It may also be used for chronic pain. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding. Effexor XR: La venlafaxine appartient à la classe des médicaments antidépresseurs et anxiolytiques appelés inhibiteurs sélectifs du recaptage de la sérotonine et de la norépinéphrine ou ISRSN. Does Depression Cause Obesity or Does Obesity Cause Depression? Venlafaxine had no effect on the pharmacokinetics of lithium (see also CNS-Active Drugs, below). Voluntary reports of other adverse events temporally associated with the use of venlafaxine that have been received since market introduction and that may have no causal relationship with the use of venlafaxine include the following: There have been reports of elevated clozapine levels that were temporally associated with adverse events, including seizures, following the addition of venlafaxine. The more common events ( ≥ 1%) associated with discontinuation and considered to be drug-related (i.e., those events associated with dropout at a rate approximately twice or greater for venlafaxine compared to placebo) included: The most commonly observed adverse events associated with the use of venlafaxine tablets, USP (incidence of 5% or greater) and not seen at an equivalent incidence among placebo-treated patients (i.e., incidence for venlafaxine tablets, USP at least twice that for placebo), derived from the 1% incidence table below, were: The table that follows enumerates adverse events that occurred at an incidence of 1% or more, and were more frequent than in the placebo group, among venlafaxine tablets, USP-treated patients who participated in short-term (4 to 8 week) placebo-controlled trials in which patients were administered doses in a range of 75 to 375 mg/day. Patients receiving warfarin therapy should be carefully monitored when venlafaxine tablets, USP is initiated or discontinued. In an analysis of ECGs obtained in 769 patients treated with venlafaxine tablets, USP and 450 patients treated with placebo in controlled clinical trials, the only statistically significant difference observed was for heart rate, i.e., a mean increase from baseline of 4 beats per minute for venlafaxine tablets, USP. The frequencies presented, therefore, represent the proportion of the 5356 patients exposed to multiple doses of either formulation of venlafaxine who experienced an event of the type cited on at least one occasion while receiving venlafaxine. WebMD does not provide medical advice, diagnosis or treatment. Ce médicament ne doit pas être associé à un traitement par IMAO (Inhibiteurs Irréversibles de la Monoamine-Oxydase). Therefore, it is generally recommended that the dose of anti-depressant be reduced gradually when therapy is discontinued. Venlafaxine AUC increased by 21% in EM subjects and 70% in PM subjects (range in PMs - 2% to 206%), and AUC values for ODV increased by 23% and 33% in EM and PM subjects (range in PMs - 38% to 105%) subjects, respectively. Therefore, the potential exists for a drug interaction between drugs that inhibit CYP2D6-mediated metabolism and venlafaxine. Problem With Ejaculation 16. Effexor (venlafaxine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant used to treat depression, depression with associated symptoms of anxiety, generalized anxiety disorder, social anxiety disorder, and adults with panic disorder. These findings have been confirmed in a clinical drug interaction study comparing the effect of venlafaxine to that of fluoxetine on the CYP2D6-mediated metabolism of dextromethorphan to dextrorphan. However, there is a dose dependency for blood pressure increase. In a flexible-dose study, with doses in the range of 200 to 375 mg/day and mean dose greater than 300 mg/day, the mean change in heart rate was 8.5 beats per minute compared with 1.7 beats per minute for placebo. Many people taking venlafaxine will not experience any major side effects. The overall pharmacological activity of venlafaxine plus ODV is expected to increase only slightly, and no dosage adjustment should be necessary for most normal adults. Side Effects of Using Effexor. * Percentages based on the number of males. Numbness And Tingling 15. The cited figures, however, do provide the prescribing physician with some basis for estimating the relative contribution of drug and nondrug factors to the side effect incidence rate in the population studied. Venlafaxine also did not have any effect on the pharmacokinetics of diazepam or its active metabolite, desmethyldiazepam, or affect the psychomotor and psychometric effects induced by diazepam. Feel Like Throwing Up 9. In controlled clinical trials, venlafaxine tablets, USP was associated with mean increases in diastolic blood pressure ranging from 0.7 to 2.5 mm Hg averaged over all dose groups, compared to mean decreases ranging from 0.9 to 3.8 mm Hg for placebo. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses and investigators. In addition, in premarketing assessment of venlafaxine hydrochloride extended-release capsules, multiple doses were administered to 705 patients in Phase 3 major depressive disorder studies and venlafaxine tablets, USP was administered to 96 patients. Some side effects may occur whether the drug is administered as recommended or misused. In vitro studies indicate that venlafaxine is a relatively weak inhibitor of CYP2D6. Knowing the side effects of Effexor will make the experience of taking it much easier on both you and your family. All reported events are included except those already listed in TABLE 2 and those events for which a drug cause was remote. Treatment of depression in adolescents may involve psychotherapy and medications. Indinavir did not affect the pharmacokinetics of venlafaxine and ODV. Venlafaxine did not inhibit CYP3A4 in vitro. Blurred Vision 2. SNRI antidepressant, Effexor, may cause a number of side effects which can result in serious illness or injury. Treatment may involve psychotherapy and medication. The rule for including events was to enumerate those that occurred at an incidence of 5% or more for at least one of the venlafaxine groups and for which the incidence was at least twice the placebo incidence for at least one venlafaxine tablets, USP group. Discontinuation effects have been reported in patients receiving venlafaxine. That doesn't mean, though, it's normal. Concomitant use of CYP3A4 inhibitors and venlafaxine may increase levels of venlafaxine and ODV. Does Effexor XR interact with other medications? In vitro studies revealed that venlafaxine has virtually no affinity for opiate, benzodiazepine, phencyclidine (PCP), or N-methyl-D-aspartic acid (NMDA) receptors. Venlafaxine did not affect the pharmacokinetics of imipramine and 2-OH-imipramine. Some people report experiencing "brain shivers" or “brain zaps” when they are late taking their prescribed dose of Effexor.2 People often describe these sensations as a very brief, repetitive electric shock-like feeling that remains confined to the brain or head. Altered anticoagulant effects, including increased bleeding, have been reported when SSRIs and SNRIs are coadministered with warfarin. Not knowing all the side effects of any medication can be not only dangerous but also confusing when the patient’s body begins to change. In addition, the haloperidol Cmax increased 88% when coadministered with venlafaxine, but the haloperidol elimination half-life (t½) was unchanged. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. https://www.dailymotion.com/video/x7txcs_effexor-le-danger-de-la-venlafaxine_tech Learn simple... False ideas scare many depression suffers away from therapy and the quick relief and help these pros can provide. Most Frequently Reported Side Effects Nausea, dry mouth and tiredness are the most commonly reported side effects. Many experts believe that an imbalance among neurotransmitters is the cause of depression as well as other psychiatric disorders. The clinical relevance of this finding for hypertensive patients is unknown. Therefore, caution is advised should a patient's therapy include venlafaxine and any agent(s) that produce potent simultaneous inhibition of these two enzyme systems. Venlafaxine administered under steady-state conditions at 150 mg/day in 24 healthy subjects decreased total oral-dose clearance (CI/F) of a single 2 mg dose of haloperidol by 42%, which resulted in a 70% increase in haloperidol AUC. Venlafaxine appeared to reduce the blood pressure lowering effect of metoprolol in this study. There are a lot of negative experiences on here, so I wanted to share my positive one to offset this. changes in the sense of smell, and taste. It is therefore recommended that you avoid the use of alcohol while on Effexor, and while you come off the drug. Effexor side effects (and this would include other antidepressants as well as Effexor) may cause permanent brain damage. Side effects of Effexor that are different from Lexapro include nervousness, headaches, anxiety, strange dreams, increased sweating, blurred vision, changes in appetite, increased blood pressure, and seizures. Side effects of Lexapro that are different from Effexor include upset stomach, gas, heartburn, yawning, and ringing in the ears. Effexor is a newer antidepressant drug. Serotonin release by platelets plays an important role in hemostasis. Venlafaxine treatment has been associated with dose-related increases in blood pressure in some patients. It is recommended that patients receiving venlafaxine tablets, USP have regular monitoring of blood pressure. Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. Effexor should only be taken as prescribed by a doctor. While it is reported that sexual side effects tend to decrease the longer you take Effexor, it is important to know there is no well documented time-frame. Common side effects of Effexor include nausea, headaches, anxiety, insomnia, drowsiness, loss of appetite, dizziness, ejaculation disorder, sweating, dry mouth, and weight loss. Psychologist Gary Greenberg expressed his concern, citing studies that showed high doses of these drugs cause changes in neurons.The more dramatic side effects, such as violent impulses and agitation amazingly have not been confirmed or disproved in the psychiatric … Effexor is available in an extended release formulation (Effexor XR). Select a condition to view a list of medication options. Side effects of Effexor include I'd call your doctor if you keep having severe side effects but for me, it's been a life saver and you WILL notice differences sooner than later. It is common for doctors to begin patients on a low dose of Effexor and adj… Certain patients may experience stomach-related side effects of Effexor during treatment 1. Effexor XR (venlafaxine) is a prescription drug that’s used to treat depression, anxiety, and panic disorder. My advice, with my experience with it, is to stick with it. Things to remember when you fill your prescription. Therefore, caution is advised if a patient €™s therapy includes a CYP3A4 inhibitor and venlafaxine concomitantly. However, there are people out there that have been on this powerful antidepressant for years. Dry Mouth 7. These can include nausea, vomiting or stomach pain. This finding was confirmed in vivo by clinical drug interaction studies in which venlafaxine did not inhibit the metabolism of several CYP3A4 substrates, including alprazolam, diazepam, and terfenadine. Venlafaxine was not found to have any significant CNS stimulant activity in rodents. Folk remedies and half-truths still prevent many from getting treatment for depression. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease). Excessive Sweating 8. A comparison of adverse event rates in a fixed-dose study comparing venlafaxine tablets, USP 75, 225, and 375 mg/day with placebo revealed a dose dependency for some of the more common adverse events associated with venlafaxine tablets, USP use, as shown in the table that follows. Venlafaxine tablets, USP is not a controlled substance. Effexor and Insomnia. with a single dose of venlafaxine 50 mg in extensive metabolizers (EM; n = 14) and 25 mg in poor metabolizers (PM; n = 6) of CYP2D6 resulted in higher plasma concentrations of both venlafaxine and O-desvenlafaxine (ODV) in most subjects following administration of ketoconazole. Find everything you need to know about Effexor (Venlafaxine), including what it is used for, warnings, reviews, side effects, and interactions. * Based on the number of men and women as appropriate. Patients who are started on therapy should be closely observed for clinical worsening, suicidality, or unusual changes in behavior. There have been reports of increases in prothrombin time, partial thromboplastin time, or INR when venlafaxine was given to patients receiving warfarin therapy. Learn about side effects, dosage, and more. Now they have put me back on it at 150 mg. BTW (Not super long ago I had a purposeful OD on it and I was off it for a while.) extreme apprehension or fear of social interaction, muscle weakness associated with sleeping disease, disturbance in the ability of the eye to focus, a feeling of restlessness with inability to sit still, an inability to completely empty the bladder, altered interest in having sexual intercourse, a disorder with excess antidiuretic hormone called syndrome of inappropriate antidiuretic hormone, low blood counts due to bone marrow failure, very low levels of granulocytes, a type of white blood cell, low levels of a type of white blood cell called neutrophils, tardive dyskinesia, a disorder characterized by involuntary movements of the face, mouth and tongue, extrapyramidal disease, a type of movement disorder, neuroleptic malignant syndrome, a reaction characterized by fever, muscle rigidity and confusion, serotonin syndrome, a type of disorder with high serotonin levels, torsades de pointes, a type of abnormal heart rhythm, ventricular fibrillation, a heart rhythm disorder, orthostatic hypotension, a form of low blood pressure, a type of inflammation of the lung called interstitial pneumonitis, pneumonia with high amount of eosinophil white blood cells, inflammation of the liver called hepatitis, erythema multiforme, a type of allergic skin reaction, a skin disorder with blistering and peeling skin called toxic epidermal necrolysis, a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome, a condition with muscle tissue breakdown called rhabdomyolysis, fluid retention in the legs, feet, arms or hands, a significant type of allergic reaction called anaphylaxis, a type of allergic reaction called angioedema, secondary angle-closure glaucoma, a type of eye disorder, abnormally acute hearing or painful sensitivity to sound, inflammation of the tissue lining the sinuses, increased sensitivity of the skin to the sun.
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